The breakthrough is another major step towards developing a commercially viable drug version based on teixobactin - a natural antibiotic discovered by US scientists in soil samples in 2015 which has been heralded as a "gamechanger" in the battle against antibiotic resistant pathogens such as MRSA and VRE.."Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins", said Ishwar Singh from the University of Lincoln&lipstick cases for sale39;s School of Pharmacy. Our preliminary studies suggest that the modified peptide decreases the bacterial burden as well as disease severity, thus potentially enhancing the therapeutic utility, said Rajamani.The development of new antibiotics which can be used as a last resort when other drugs are ineffective is therefore a crucial area of study for healthcare researchers around the world, they said.It has been predicted that by 2050 an additional 10 million people will succumb to drug resistant infections or superbugs each year, researchers said.After these simplified synthetic versions were shown to be highly potent against superbug-causing bacteria in vitro - or test tube - experiments, researchers from the Singapore Eye Research Institute then used one of the synthetic versions to successfully treat a bacterial infection in mice.

Scientists from the University of Lincoln in the UK successfully created a simplified, synthesised form of teixobactin which has been used to treat a bacterial infection in mice, demonstrating the first proof that such simplified versions of its real form could be used to treat real bacterial infection as the basis of a new drug."When teixobactin was discovered it was groundbreaking in itself as a new antibiotic which kills bacteria without detectable resistance including superbugs such as MRSA, but natural teixobactin was not created for human use", Singh said.Drugs that target the fundamental mechanism of bacterial survival, and also reduce the host's inflammatory responses are the # need of the hour.Indian-origin scientists have developed a novel "game changing" antibiotic which is capable of killing drug-resistant bacteria, and could lead to the first new class of antibiotic drug in 30 years."We need sophisticated armour to combat antibiotic-resistant pathogens", Lakshminarayanan Rajamani from SERI added.As well as clearing the infection, the synthesised teixobactin also minimised the infection's severity, which was not the case for the clinically-used antibiotic, moxifloxacin, used as a control study, according to the finding published in the Journal of Medicinal Chemistry.They developed a library of synthetic versions of teixobactin by replacing key amino acids at specific points in the antibiotic's structure to make it easier to recreate.

. It’s the latest multi-platform device offering non-surgical skin tightening and lifting as well as addressing fine lines and wrinkles, giving your skin the fresh, glossy, smooth look which you are looking for an excellent in case of necklines and wrinkles. We may have forgotten to include your neck and décolleté in your daily skin-care routine. Grid Fractional RF was also known as Thermage, delivers heat and energy to the collagen fibers of the skin causing the upper layers of the skin to tighten.LAYER 2: Contraction of the dermis. Your dermatologist will instruct you with a bespoke homecare regime that will ensure maintenance of the results. Even drastic weight loss and gain in a short time can cause the skin on your neck to expand and contract, leading to sagging skin and pronounced neck bands and neck wrinklesULTRAcel is a fantastic treatment for tightening loose skin on the face and neck.Treatment benefits1. This stimulates the growth of new and healthy collagen, which uplifts skin to feel and look firmer and tighter.— The writer is a dermatologist.LAYER 3: Contraction of the muscular layers (SMAS)  High intensity focused Ultrasound waves are used to target a layer of tissue that previously could only be improved with surgery. Exposure to the sun’s harmful rays can break down collagen and elastin, causing the skin to lose its flexibility, resulting in etched-in necklines. By combining Radiofrequency with Ultrasound, ULTRAcel is able to target and deliver heat to collagen in the deeper layers of the skin. Disclaimer: Always check with a dermatogist/cosmetic surgeon before going ahead with this procedure. Tighten sagging skin and rejuvenate skin tone and give a more defined jawline and disappearance of fine lines and wrinkles on the neck as well.

The Aluminum Eyeliner Tubes wholesale treatment has been used by many famous celebs Gwyneth Paltrow, Bethenny Frankel, and Jennifer Aniston.We’re all a little conscious about that double chin right above our necks. Safe and proven skin tightening procedure that has minimal downtime, with most patients able to return to their regular routine on the same day as treatment4. Neglecting to care for it just as you do your face leaves it more susceptible to developing wrinkles and bands over time also due to genetics or years of neglecting the skin below your face, the lines across your neck are difficult to conceal and lead to neck wrinkles. Ideal for scaring. It usually costs around 65-70 thousand per session.. Completely non-invasive (no need for surgery)3.Three modalities of the treatment that can be used alone or in combination-LAYER 1: Contraction of the superficial epidermis. Facial exercises can tone and strengthen the underlying neck musclesWe recommend that you maintain a good diet and an active lifestyle. As this treatment is totally non-invasive, it’s a great option for those who do not have time for downtime. This can cause plumping and tightening of the skin.2. With this new improved treatment you can get rid of it easily! Picture of Gwyneth Paltrow (Representational Image) As we age, our skin loses water and collagen content, and as a result, it becomes drier and less firm. The superficial muscular aponeurotic system (SMAS) will tighten and contract as a direct result of the focused thermal energy applied to it. Fractional Radiofrequency Micro needling (FRM)) involves energy being delivered deeper into the tissue combining the benefits of deeper RF collagen stimulates as well as unprecedented collagen remodeling caused by micro needling.

With these small steps we can help in overcoming the water shortage crisis in Leh and the nearby villages. Save Water to Save Leh!(Charkha Features).If natural springs dry up then ways and means of recharging them should be found. Hotels and cafes should try and use the traditional dry toilets of Ladakh more instead of the modern flush toilets which consume more and more water. The question will not just stop at number of borewells but how much water they extract from the ground.In June 2018 freelance journalist Basharat Ladakhi told the Sunday Guardian Live that in the past two years more than 1,000 new hotels and guest houses have been constructed in and around Leh and hundreds of new constructions in Leh were going on, but most of the hoteliers and guest house owners were banking on tankers to supply water.“It is a crisis and the governments will have to intervene to save the Ladakh region from water shortage.“Almost all the households, hotels and guesthouse have their own private borewell and there is no regulation on it. Their number was restricted to 25,000-30,000 each year.A 50 year old farmer from Chuchot Yakma village, Chuchot Block, Rinchen Dolma says, “From 1985 the snowfall has decreased year after year.

But after that, domestic tourists started coming in large numbers. The tube wells are also running dry at many places as groundwater level is falling fast all over Ladakh, especially in Leh. Researchers and environmentalists have claimed that the depleting water levels are because of the erratic weather conditions and more so because of climate change in the past decade. The department is supplying drinking water for two hours in the morning and two hours in the evenings; the taps are dry for the rest of the day. A young girl in Leh struggles to fill her water can Leh may be on the brink of drinking water scarcity with the public health engineering (PHE) department curtailing water supply to Leh town and its surrounding villages beginning this month. We should try to minimise the use of natural spring water as much as possible. It requires a comprehensive study,” Nordan Otzer, executive director, Ladakh Ecological Development Group told Down To Earth Magazine in July 2018.” Domestic tourist arrival grew by 43 per cent and foreign tourist arrival by 28 per cent between 2015 and 2017. Rain water harvesting could be one solution of recharging the depleting ground water reserves. Artificial glaciers should be formed to save ground water and then we should preserve the natural glaciers. The glaciers are melting at a fast pace and even the ground water levels are not good for the people of Ladakh during the current summer season. To solve the water problems we have to use less and less of water.

According to another farmer from Chuchot Yakma village of Chuchot Block, 46 year of Stanzin Angmo, “The number of tourists coming to the lakes increases with the temperature. All the springs within Leh town have dried up and, we believe it is the impact of ground water exploitation.In July 2018 Tsering Sandup, Executive Councillor (Tourism) at Ladakh Autonomous Hill Development Council told Down To Earth magazine “Before 2005, Ladakh used to receive mainly foreign tourists.Hundreds of water tankers carry water on a daily basis to the hotels and the guest houses, but the receding water levels have already rattled the authorities.The department is supplying drinking water for two hours in the morning and two hours in the evenings. Hotels and cafes use lots of water for washing dishes and while using the flush toilets.”In Leh town the water shortage is a big problem. The decreasing of snow has become a huge crisis for the people of Chuchot village as well as for the China mascara case factory people of Stok village, Chuchot Block because both these villages are totally dependent on the snowfall”. There are protests going on against water crisis in many villages of Leh” said 46 year old Kunnes Angmo, a farmer from Chuchot Yogma village in Leh distrct.

Mumbai: Come June 16, you need to be aware of the day’s fuel price if you want to take your car on the road. Any such decision shall wipe out his entire China Daily Cosmetic Tube Suppliers working capital if the prices were to go down frequently," it said.."The daily price revision is an initiative for ensuring the best possible prices to the customers as well as improved transparency in the pricing mechanism," Indian Oil Corporation Limited (IOCL), the country's largest oil retailer said. Representational Image. "One tank lorry of 18 Kls lasts most of such small dealers 7 to 10 days.Indian Oil had said, three the OMCs will “establish an appropriate mechanism” to convey the prices to consumers every day. This can be set to automatically come into effect at midnight at the automated ROs (Retail Outlets), without manual intervention," it said. While petrol pumps will be displaying the daily prices, there are various other ways to check these dynamic rates. They are crying at the inventory loss that they have already suffered due the fluctuations in the daily changing prices on the inventory held by them," it said in a statement.However, the Federation of All India Petroleum Traders (FAIPT), has voiced its protest against the government’s decision to implement daily revision of fuel prices.IOCL also said it would train dealers at petrol pumps to ensure that customers do not face any pricing misinformation or glitches. Alternatively, customers can also check the prices in their cities by sending SMS RSPDEALER CODE to 92249-92249.Customers can access IOCL’s mobile app Fuel@IOC for the rates.The federation also claimed 50 per cent of petrol pumps sell 30 kilolitre of fuel per month on an average. Petrol and fuel prices are all set to undergo daily revision by state-run oil marketing companies (OMC) from this Friday. It  has claimed that there will bell be "no purchase no sale" of petrol and diesel on June 16.  "Dealers of five cities where it was launched have already burnt their fingers.At the non-automated petrol pumps, dealers will be receiving the updated price via customised SMSs, e-mails, mobile app & web portal for dealers. "All the 26,000 plus Indian Oil dealers will be given timely information on the effective prices at a pre-designated time - say 20:00 hrs for the next day.Indian Oil had said, the three oil manufacturing companies will “establish an appropriate mechanism” to convey the prices to consumers every day. “The Dealer Code of each petrol pump would be prominently displayed in the petrol pump premises," IOCL said. This initiative follows the successful implementation of the pilot project in Udaipur, Jamshedpur, Vishakhapatnam, Chandigarh and Puducherry from May 1.

Instead of using fortnightly average, pump rates will reflect daily movement in international oil prices and rupee- US dollar fluctuations.Daily price change will remove Lip Gloss Tubes for sale the big leaps in rates that need to be effected at the end of the fortnight and consumer will be more aligned to market dynamics.68 a litre.State-owned fuel retailers Indian Oil Corp (IOC), Bharat Petroleum Corp Ltd (BPCL) and Hindustan Petroleum Corp Ltd (HPCL), which own more than 95 per cent of the nearly 58,000 petrol pumps in the country, will launch a pilot for daily price revision in five select cities from 1 May 2017 and gradually extend it to other parts of the country. In Puducherry, petrol is priced at Rs 66.Technically, oil companies have freedom to revise rates but often they have been guided by political considerations.02 per litre and diesel Rs 58.65 in Chandigarh and diesel is priced at Rs 57.Rates differ by only a few paise between pumps of the three state fuel retailers. New Delhi: Petrol and diesel prices will be revised on a daily basis from today in select towns in sync with international rates, much like it happens in most advanced markets. In Vizag, petrol costs Rs 72.57 a litre and diesel Rs 61.23, while in Jamshedpur petrol costs Rs 69.33 a litre and diesel Rs 60.While petrol price was freed from the control of the government in June 2010, diesel rates were deregulated in October 2014.68 a litre and diesel Rs 62.A litre of petrol costs Rs 67.26.Daily price change will remove the big leaps in rates that need to be effected at the end of the fortnight.74.State fuel retailers currently revise rates on the 1st and 16th of every month based on average international price of fuel in the preceding fortnight and currency exchange rate.With daily changes, which are unlikely to be more than a few paise per litre, the political pressures for not revising rates particularly when they are to be hiked will go, industry sources said.A pilot for daily revision of petrol and diesel prices will be first implemented in Puducherry, Vizag in Andhra Pradesh, Udaipur in Rajasthan, Jamshedpur in Jharkhand and Chandigarh, IOC said in a statement.IOC said petrol in Udaipur costs Rs 70. IOC said customers may verify fuel prices by downloading the company app or visiting its website..IOC said customers may verify fuel prices by downloading the company app or visiting its website.81.

Skoda has launched a more affordable variant of its entry-level sedan - the Rapid-  to make it more accessible to customers.5 TDI MT Ambition(Source: ZigWheels.44 lakh The special edition model comes with a host of cosmetic updates to make it more appealing. It will only be available with the petrol engine. The Rapid Rider Edition is around Rs 1 lakh cheaper than the Active variant it is based on.The Rapid Rider Edition can only be had with the 1.99 lakhActive MTRs 8.Features list remain the same as the Active variant.99 lakh (ex-showroom India).Note: Image used for representational purposes.Gets cosmetic updates and competitive price tag to capture buyers from a segment below.Here’s a look at where the new Rider Edition slots in the Rapid lineup:Skoda Rapid PETROLPrices (ex-showroom India)Rider EditionRs 6.6-litre MPI petrol unit that churns out 105PS and 153Nm.It comes with a host of cosmetic updates to make it more appealing.00 lakhStyle MTRs 10.00 lakhAmbition MTRs 9.36  lakhStyle ATRs 12.00 lakhAmbition ATRs 11.The features list on the Rider Edition remains the same as the Active variant it is based on. Hence, it still sports goodies like a 2-DIN audio system with Bluetooth connectivity, remote central locking, front and rear power windows, front and rear armrest, manual air conditioner and electrically adjustable ORVMs. Skoda Rapid Rider is around Rs 1 lakh cheaper than the Active variant it is based on.5-litre TDI that churns out 110PS and 250Nm is not available with the new special edition.It is only available with a petrol motor and a 5-speed manual gearbox. But thanks to the attractive price of the special edition sedan, it aims to eat into the market share of popular compact sedans like the Ford Aspire, Honda Amaze, Hyundai Xcent as well as the Maruti Suzuki Dzire.The Skoda Rapid rivals the Volkswagen Vento, Honda City, Hyundai Verna and the Maruti Suzuki Ciaz. Changes on the interiors are limited to a scuff plate with ‘Rapid’ inscription.Recommended Variant : Rapid 1.Also Read: 2020 Skoda Octavia Interiors SpiedIt also comes with safety features like dual airbags, ABS with EBD, seatbelt reminder, rough road package and rear parking sensors as standard. This makes it around a lakh cheaper than the base petrol Active variant on which it is lipstick cases manufacturers based.41kmpl (claimed). Note: Image used for representational purposes. Called the Rapid Rider, the new variant is priced at Rs 6.Note: Image used for representational purposes. Claiming to offer six years of hassle free ownership, this includes motor insurance, 24X7 roadside assistance and an extended warranty.Also Read: Skoda Superb Facelift India Launch By Mid-2020The Rapid Rider Edition can also be had with Skoda Shield Plus as standard for complete peace of mind. It comes mated to a 5-speed manual gearbox and returns 15. The Rapid Rider Edition is offered in two colours -- Carbon Steel and Candy White. On the outside, the Rider Edition features a black finish on the grille and B-pillar, black colour body graphics on the doors and a black colour trunk lip garnish.com).

– The writer is a  cosmetic surgeonDisclaimer: Always check with a cosmetic surgeon before going ahead with this procedure. The hyaluronic acid is a protein molecule which is made in the lab. Aged hands can be treated using fillers. The most popular fillers for hand rejuvenation are the semi permanent hyaluronic acid fillers like restylane, juvederm, belotero or non hyaluronic acid fillers made up of calcium hydroxyapaptite like radiesse which is still not available in India. Hence as skin becomes less elastic, it forms lines and folds.As we grow older, the collagen in the skin breaks down every year and the rate at which we make it is not enough mascara case manufacturers to compensate for the rate at which it is breaking down. The filler is injected either with a needle or with a soft blunt needle called a ‘cannula’ which causes lesser bruising.Hyaluronic acid fillers have the property of binding water molecules thereby plumping, lifting and filling spaces. The risk of allergy to this molecule when injected is extremely low. You can apply arnica or Vit K cream to avoid bruisingAvoid alcohol for 48-72 hours post injection.When Should one go for this : When you feel your hands are looking drier, the skin over them is looking less hydrated, wrinkly or when you pinch your skin and leave it you can see it takes some time to come back to rest meaning it is less elastic, you can opt for this treatment. Avoid makeup for 24 hours post injection. After injecting all the areas the hand is massaged with a barrier cream to smooth out all bumpy areas.Your hands don’t look as young as your feel? Leave it to hand re-juvenation fillers to do the work for you! A picture of Jennifer Aniston used for representational purposes only Reversing the aging effects on hands may not seem important to all but for some it is. If the lumps and bumps persist after three to four days consult your injecting doctor. Expect some swelling for a few days and sometimes some lumps and bumps may appear.Procedure: After taking consent and before pictures, the skin is cleansed thoroughly and under a sterile technique the doctor injects the filler in the areas of volume loss over the back of the hands. You may require one to four ml as per signs. If there are any concerns like redness, numbness, discoloration consult your doctor immediately.Cost : Price depends on the amount of volume loss or ageing signs. Most doctors charge per ml of filler which can range anything from Rs 20,000 to Rs 40,000 per ml.How long it lasts : The results can last to a year and a year-and-a-half depending on the heaviness of the filler used but also other factors such as smoking, sun exposure, alcohol, diabetes etc will all dictate how soon the filler will be broken down. If there is any bruising immediately ask your doctor who will apply ice and compression. Fillers can be of various kind s– permanent, semi permanent and hyaluronic acid or non hyaluronic acid.Hyaluronic acid fillers can be used wherever there is volume loss to fill in the depths of the folds to plump and lift..  Do’s and Dont’s: Do not touch the area post injection or massage anymore.

Implants or cartilage can also be inserted to build up areas to produce a better looking nasal structure. A file picture of Sara Sampaio used for representational purposes only. Smoking and usage of nicotine patches must be strictly avoided too. The fat is then prepared and injected into the recipient site with a needle.For people seeking lip augmentation, there are mainly two alternatives. During this procedure, the compound is injected using a fine needle at several points along the edge of the treatment site.Cosmetic surgery for lip and nose consists of the enlargement and reshaping of otherwise normal lips to improve their dimensional relation with the patient’s nose, teeth, and surrounding facial structures.). Some basic blood test will be required. The first is HA fillers. The Doctor may ask you to obtain an X-ray, CT scan or computer imaging of your nose prior to surgery. The nasal cartilage can be altered to allow a thinner bridge and narrower appearance. Wider nose when viewed from the front and the nose being off-centre or crooked are the most common problems people notice. It’s purpose is to correct the shape of  the outside of the nose, to remove eyeliner cases bumps from the bridge of the nose or to lift a drooping tip.Various types of alterations can be made to the nose.The writer is a cosmetic surgeon. This is when the augmentative procedure comes as a solution. If a local anesthesia has not been used, you may feel minor stinging or burning as the injections are administered. Some patients have a hump on the bridge of their nose, which can be chiselled down, making it less visible. Small and deflated lips, asymmetric features, reconstructive needs, drooping or sagging upper lip are some of them.Preparing for the procedure is very simple. Changes can be made to the septal bone if it is crooked. If the nose is bent, it can be straightened and changes can also be made to lift a drooping tip. If you have had doubts about whether you’re a candidate for augmentation, there are certain telling signs.(Disclaimer: Always check with an expert before going ahead with such treatment. Intake of any blood thinning tablets should be avoided while intake of vitamins at least one week prior to surgery is prescribed.The second one is Autologous Fat Augmentation. Often people feel like their nose appears too large for their face or that there’s a bump on the nasal bridge when viewed in profile.If you are discontented with the asymmetry of your facial features, this treatment offers a brilliant sollution. Sometimes a previous injury can make the nose asymmetrical too. This is performed by re-breaking the nasal bone and straightening it, allowing the patient to breathe easier. After both the donor and recipient sites are cleansed and treated with a local anaesthesia, the fat is withdrawn using a syringe with a large-bore needle or a cannula (the same instrument used in liposuction) attached to a suction device.

They created a library of more than 100 possible polymers, all of which contained a chemical structure known as siloxane — a chain of alternating atoms of silicon and oxygen.The best-performing material has elastic properties very similar to those of skin. This type of “second skin” could also be adapted to provide long-lasting ultraviolet protection, researchers said. This impairs skin’s ability to protect against extreme temperatures, toxins, microorganisms, radiation, and injury. It easily returned to its original state after being stretched more than 250 per cent. These polymers can be assembled into a network arrangement known as a cross-linked polymer layer (XPL). The researchers then tested the materials in search of one that would best mimic the appearance, strength, and elasticity of healthy skin.The material, a silicone-based polymer that may be applied on the skin as a thin, imperceptible coating, mimics the mechanical and elastic properties of healthy, youthful skin.The researchers, including Alpesh Patel, formerly at US-based beauty company Living Proof, and Nithin Ramadurai from Olivo Laboratories, set out to develop a protective coating that could restore the properties of healthy skin, for both medical and cosmetic applications. As skin ages, it Eyeliner Tubes for sale becomes less firm and less elastic — problems that can be exacerbated by sun exposure.In tests with human subjects, the researchers found that the material was able to reshape “eye bags” under the lower eyelids and also enhance skin hydration.. “It’s an invisible layer that can provide a barrier, provide cosmetic improvement, and potentially deliver a drug locally to the area that’s being treated,” said Daniel Anderson, from Massachu-setts Institute of Technol-ogy (MIT).Scientists, including those of Indian-origin, have developed a new material that can temporarily tighten skin, smooth wrinkles, and may be used to deliver drugs to treat skin conditions such as eczema Scientists, including those of Indian-origin, have developed a new material that can temporarily tighten skin, smooth wrinkles, and may be used to deliver drugs to treat skin conditions such as eczema.

"When they saw a train coming, all three were extremely fortunate in being able to move into a pit under the track and the train passed safely over the top of them.The woman was pushing her child in the buggy along the platform while looking up at the board that indicates when the next train will arrive. London: A lipstick cases factory mother and her child who fell onto the track on the London Underground narrowly avoided being hit by a train by hiding in a pit beneath the rails, police said Saturday.. 'Amazingly none of them were seriously hurt, but as a precaution they were taken to hospital for check-ups,' said a statement from the British Transport Police.They narrowly avoided being hit by a train by hiding in a pit beneath the rails."She didn't realise how near she was to the edge of the platform and accidentally pushed the buggy wheels over it," the statement said. The father jumped down to help them.37 billion passengers travel on the Tube each year, and in 2017 more than 3,000 injuries were recorded, according to figures from the Transport for London operating body."An estimated 1.The child's father also took shelter as the train passed overhead, after jumping down to help them on Friday evening at Baker Street Tube station."Amazingly none of them were seriously hurt, but as a precaution they were taken to hospital for check-ups," said a statement from the British Transport Police."She, the buggy and the child fell onto the track.Nigel Holness, director of network operations at Transport for London, said he was "relieved" the family was unharmed but emphasised the need for travellers to stand back from the platform edge.